Cutaneous Ewing sarcoma: report of 2 cases and literature review of presentation, treatment, and outcome of 76 other reported cases

J Pediatr Hematol Oncol. 2011 Dec;33(8):631-4. doi: 10.1097/MPH.0b013e31821b234d.

Abstract

Cutaneous Ewing sarcoma is a rare variant that has been poorly characterized and has no standard therapy. We report 2 patients with cutaneous Ewing sarcoma and review 76 other cases reported in the literature for demographics, presentation, treatment, and outcome. Only 2 patients presented with metastatic disease, and only 8 patients developed metastatic disease. Ninety-one percent of all patients are alive despite wide variations in treatment regimens. On the basis of this summary, treatment consisting of local control with surgery and/or radiation and abbreviated chemotherapy is proposed as a treatment option for this less aggressive Ewing sarcoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Chemoradiotherapy*
  • Child
  • Female
  • Humans
  • Remission Induction
  • Sarcoma, Ewing* / pathology
  • Sarcoma, Ewing* / surgery
  • Sarcoma, Ewing* / therapy
  • Skin Neoplasms* / pathology
  • Skin Neoplasms* / surgery
  • Skin Neoplasms* / therapy
  • Treatment Outcome