Abstract
A structure-activity study of several new synthetic analogues of the avocado-produced toxin persin has been conducted, with compounds being evaluated for their cytostatic and pro-apoptotic effects in human breast cancer cells. A 4-pyridinyl derivative demonstrated activity comparable to that of the natural product, suggesting future directions for exploration of structure-activity relationships.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemical synthesis
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Breast Neoplasms / drug therapy*
-
Breast Neoplasms / pathology
-
Cell Line, Tumor
-
Fatty Alcohols / chemical synthesis
-
Fatty Alcohols / chemistry*
-
Fatty Alcohols / pharmacology*
-
Female
-
Humans
-
Persea / chemistry*
-
Plant Extracts / chemical synthesis
-
Plant Extracts / chemistry
-
Plant Extracts / pharmacology
-
Structure-Activity Relationship
Substances
-
Antineoplastic Agents, Phytogenic
-
Fatty Alcohols
-
Plant Extracts
-
persin