Tumor bombesin analog loaded long-circulating and pH-sensitive liposomes as tool for tumor identification

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7373-5. doi: 10.1016/j.bmcl.2011.10.016. Epub 2011 Oct 13.

Abstract

Long-circulating and pH-sensitive liposomes trapping (99m)Tc-HYNIC-βAla-bombesin((7-14)) (aSpHL-(99m)Tc-BBN((7-14))) were successfully prepared. Biodistribution studies and scintigraphic images were performed in Ehrlich tumor-bearing Swiss mice. This system showed high accumulation in tumor tissue with high tumor-to-muscle ratio. Therefore, aSpHL-(99m)Tc-BBN((7-14)) could be considered as a potential agent for tumor diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bombesin / administration & dosage
  • Bombesin / analogs & derivatives*
  • Bombesin / pharmacokinetics
  • Carcinoma, Ehrlich Tumor / diagnosis
  • Hydrogen-Ion Concentration
  • Isotope Labeling
  • Liposomes / chemistry*
  • Mice
  • Radiopharmaceuticals / administration & dosage
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / pharmacokinetics
  • Technetium / chemistry
  • Tissue Distribution

Substances

  • Liposomes
  • Radiopharmaceuticals
  • Technetium
  • Bombesin