PTEN, tau-AP-3, thymidylate synthase immunohistochemistry scoring expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignancy potential and uterine leiomyosarcomas

L C Huang; J C Ye; C H Hsieh; L M Chen; T Y Lin; Y C Hung; W C Chang

PTEN, tau-AP-3, thymidylate synthase immunohistochemistry scoring expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignancy potential and uterine leiomyosarcomas

Eur J Gynaecol Oncol. 2011;32(5):496-9.

Authors

L C Huang¹, J C Ye, C H Hsieh, L M Chen, T Y Lin, Y C Hung, W C Chang

Affiliation

¹ Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan.

PMID: 22053660

Abstract

Uterine smooth muscle tumors are frequently classified as benign and malignant. However, an assortment of mitotic counts and nuclear atypia can be indecisive between uncertain malignant potential, and malignant uterine smooth muscle tumors. We applied three immunohistochemical parameters to distinguish between cases of benign, malignant, and those with uncertain malignant histology.

MeSH terms

Biomarkers, Tumor / analysis
Female
Hematologic Neoplasms
Humans
Immunohistochemistry
Leiomyoma / metabolism
Leiomyoma / pathology*
Leiomyosarcoma / metabolism
Leiomyosarcoma / pathology*
Myoma / metabolism
Myoma / pathology
PTEN Phosphohydrolase / analysis*
Thymidylate Synthase / analysis*
Uterine Neoplasms / metabolism
Uterine Neoplasms / pathology*
tau Proteins / analysis*

Substances

Biomarkers, Tumor
tau Proteins
Thymidylate Synthase
PTEN Phosphohydrolase