Catalytic asymmetric diastereodivergent deracemization

Angew Chem Int Ed Engl. 2011 Dec 23;50(52):12631-5. doi: 10.1002/anie.201106321. Epub 2011 Nov 4.

Abstract

Your wish is my command: Deracemization is a powerful strategy wherein a racemate is converted into a 100 % yield of a single enantiopure product. A new concept in catalytic deracemization is presented, in which a racemate with n stereogenic elements can be selectively converted into each one of 2(m) (m = number of chiral centers of the product) different enantiopure products, by simple tuning of the reaction conditions.