Selective artificial transmembrane channels for protons by formation of water wires

Wen Si; Lei Chen; Xiao-Bo Hu; Gangfeng Tang; Zhenxia Chen; Jun-Li Hou; Zhan-Ting Li

doi:10.1002/anie.201106857

Selective artificial transmembrane channels for protons by formation of water wires

Angew Chem Int Ed Engl. 2011 Dec 23;50(52):12564-8. doi: 10.1002/anie.201106857. Epub 2011 Nov 4.

Authors

Wen Si¹, Lei Chen, Xiao-Bo Hu, Gangfeng Tang, Zhenxia Chen, Jun-Li Hou, Zhan-Ting Li

Affiliation

¹ Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.

PMID: 22058068
DOI: 10.1002/anie.201106857

Abstract

Lined up water molecules: Artificial transmembrane channels from pillar[5]arene monomeric and dimeric derivatives have been prepared. Single-channel conductance measurements and isotope effect experiments under acidic conditions showed selective proton transport through the channels, which were mediated by water wires formed in the pillar[5]arene backbones (see picture).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calixarenes
Crystallography, X-Ray
Membranes, Artificial*
Models, Molecular
Protons*
Quaternary Ammonium Compounds / chemistry*
Water / chemistry*

Substances

Membranes, Artificial
Protons
Quaternary Ammonium Compounds
pillar(5)arene
Water
Calixarenes