Abstract
Objective:
To investigate the chemical constituents of Carya cathayensis and their antitumor bioactivity.
Methods:
The compounds were isolated by Sephadex LH-20 and silica gel column chromatography. Their structures were identified by physicochemical properties and spectroscopic analysis. Then their cytotoxic activity was studied.
Results:
Five compounds were elucidated as chrysophanol (1), physcion (2), beta-sitosterol (3), pinostrobin(4), 4,8-dihydroxy-1-tetralone (5).
Conclusion:
Compounds 2 and 5 are isolated from Carya cathayensis for the first time. In the MTT antitumor experiments, the compounds 1,4 and 5 have the cytotoxic activity to KB cell.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification
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Anthraquinones / pharmacology
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Carya / chemistry*
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Cell Survival / drug effects
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology*
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Emodin / analogs & derivatives*
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Emodin / chemistry
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Emodin / isolation & purification
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Flavanones / chemistry
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Flavanones / isolation & purification
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Flavanones / pharmacology
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Fruit / chemistry
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Hep G2 Cells
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Humans
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Magnetic Resonance Spectroscopy
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Plant Bark / chemistry
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Tetralones / chemistry
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Tetralones / isolation & purification*
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Tetralones / pharmacology
Substances
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Anthraquinones
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Drugs, Chinese Herbal
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Flavanones
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Tetralones
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physcione
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Emodin
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chrysophanic acid
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pinostrobin