Influence of selenium on body weights and immune organ indexes in ducklings intoxicated with aflatoxin B₁

Biol Trace Elem Res. 2012 May;146(2):167-70. doi: 10.1007/s12011-011-9246-z. Epub 2011 Nov 9.

Abstract

To investigate the influence of selenium on body weights and the immune organ indexes in ducklings administrated with aflatoxin B(1) (AFB(1)), 90 7-day-old ducklings were randomly divided into three groups (groups I-III). Group I was used as a blank control. Group II was administered with AFB(1) (0.1 mg/kg body weight). Group III was administered with AFB(1) (0.1 mg/kg body weight) plus sodium selenite (1 mg/kg body weight). All treatments were given once daily for 21 days. It showed that the ducklings' bursa of fabricius, thymus indexes, and body weights in group II significantly decreased when compared with group I (P < 0.01). Furthermore, the spleen indexes significantly decreased (P < 0.01). However, the ducklings' bursa of fabricius and thymus indexes, body weights in group III ducklings significantly increased when compared with group II (P < 0.01). In addition, the spleen indexes significantly decreased (P < 0.01). These results revealed that AFB(1) significantly affect ducklings' growth and immune organs development. However, selenium significantly ameliorated the negative effects induced by AFB(1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aflatoxin B1 / toxicity*
  • Animals
  • Body Weight / drug effects*
  • Bursa of Fabricius / drug effects*
  • Bursa of Fabricius / pathology
  • Ducks
  • Organ Size / drug effects
  • Poisons / toxicity
  • Random Allocation
  • Sodium Selenite / pharmacology*
  • Spleen / drug effects*
  • Spleen / pathology
  • Thymus Gland / drug effects*
  • Thymus Gland / pathology
  • Time Factors

Substances

  • Poisons
  • Aflatoxin B1
  • Sodium Selenite