Abstract
Biochemical evidence supporting the sympathetic control of cerebrospinal fluid production has been obtained through identification of a specific beta-adrenergic-sensitive adenylate cyclase in the choroid plexus. The enzyme, which is localized in the secretory epithelium, is activated by low concentrations of isoproterenol and norepinephrine and appears separate from beta-adrenergic-sensitive adenylate cyclase present in cerebral blood vessels.
MeSH terms
-
Adenylyl Cyclases / metabolism*
-
Animals
-
Cats
-
Cattle
-
Cerebrospinal Fluid / metabolism
-
Cerebrovascular Circulation
-
Choroid Plexus / enzymology*
-
Choroid Plexus / metabolism
-
Dogs
-
Enzyme Activation / drug effects
-
Epithelium / enzymology
-
Isoproterenol / pharmacology
-
Rabbits
-
Receptors, Adrenergic / metabolism*
-
Receptors, Adrenergic, beta / metabolism*
Substances
-
Receptors, Adrenergic
-
Receptors, Adrenergic, beta
-
Adenylyl Cyclases
-
Isoproterenol