The role of HSAL (SALL) genes in proliferation and differentiation in normal hematopoiesis and leukemogenesis

Transfusion. 2011 Nov;51 Suppl 4(Suppl 4):87S-93S. doi: 10.1111/j.1537-2995.2011.03371.x.

Abstract

The National Blood Foundation (NBF) support was critical in the author's research career development. The NBF support came in the form of a start-up seed grant that she got from the American Association of Blood Banks, an organization that advances the practice and standards of transfusion medicine and cellular therapies and an organization in which she is a proud member. The NBF grant enabled her to keep up with her transfusion medicine practice while pursuing her passion to be a physician scientist. During its funding period, she was able to obtain critical preliminary bench data and to secure several National Institutes of Health grants with over a million dollars direct cost. In addition, the knowledge gained from the NBF-supported projects is currently being translated into medical practice in her lab by testing on cord blood expansion. She is looking forward to spending the upcoming years of her professional career bridging bedside observations on transfusion medicine with bench experiences and then utilizing that bench-derived knowledge in the practice of transfusion medicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Division
  • Cell Transformation, Neoplastic / genetics*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Embryonic Development / genetics
  • Female
  • Genes, p53
  • Hematopoiesis / genetics*
  • Hematopoiesis / physiology
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / physiology
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / physiology
  • Leukemia, Myeloid, Acute / genetics*
  • Lymphoma / genetics*
  • Mice
  • Mice, Knockout
  • Ovarian Neoplasms / genetics
  • Transcription Factors / deficiency
  • Transcription Factors / genetics*
  • Transcription Factors / physiology
  • Zinc Fingers / genetics*
  • Zinc Fingers / physiology

Substances

  • DNA-Binding Proteins
  • Homeodomain Proteins
  • Intracellular Signaling Peptides and Proteins
  • SALL1 protein, human
  • SALL2 protein, human
  • SALL3 protein, human
  • SALL4 protein, human
  • Sall1 protein, mouse
  • Sall2 protein, mouse
  • Sall3 protein, mouse
  • Sall4 protein, mouse
  • Transcription Factors