Human leukocyte antigen class I (A, B, C) and II (DRB1) diversity in the black and Caucasian South African population

Hum Immunol. 2012 Jan;73(1):80-92. doi: 10.1016/j.humimm.2011.10.013. Epub 2011 Oct 23.

Abstract

A cross-section of black and Caucasian South Africans (N = 302) were genotyped at high resolution (class I HLA-A, -B, -C and class II HLA-DRB1). Five new class I alleles (A*30:01:02, A*30:02:02, A*68:27, B*42:06, and B*45:07) and one new confirmatory allele (A*29:11) were identified in the black population. Alleles and haplotypes showed expected differences between the black and Caucasian populations, with the black population, on average, showing a broader spectrum of allele representation (less single allele dominance). The most prevalent alleles at the four loci in the black population were A*30:01, B*58:02, C*06:02, and DRB1*13:01 and in the Caucasian population were A*02:01:01, B*07:02:01, C*07:01, and DRB1*03:01. HLA-B, and HLA-C loci showed the strongest overall linkage disequilibrium (LD) and HLA-B/HLA-C two locus haplotypes also showed the strongest LD (D'(ij)) in both population groups. Bw allotype representation was similar between the two populations; however C allotypes differed significantly (C1 higher representation in Caucasians; C2 higher representation in blacks). HLA-A Supertype family phenotypic frequencies did not differ between the two populations, but four (B08, B27, B58, and B62) HLA-B Supertype families differed significantly. However, vaccine coverage estimation came close to 100% in both population groups, with inclusion of only four Supertype families (A1, A2, B7, B58).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Black People / ethnology
  • Black People / genetics*
  • Cohort Studies
  • Gene Frequency
  • Genetic Variation
  • Genotype
  • HLA-A Antigens / genetics*
  • HLA-B Antigens / genetics*
  • HLA-C Antigens / genetics*
  • HLA-DRB1 Chains / genetics*
  • Haplotypes
  • Humans
  • Linkage Disequilibrium
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • South Africa
  • White People / ethnology
  • White People / genetics*

Substances

  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-C Antigens
  • HLA-DRB1 Chains