Abstract
Takotsubo cardiomyopathy is a syndrome characterized by transient apical ballooning or reversible midventricular systolic dysfunction. Most cases occur in postmenopausal women and are typically triggered by an acute medical illness or emotional or physical stress. Its presentation is highly suggestive of myocardial ischemia, but there is little or no evidence of epicardial coronary artery disease. To our knowledge there are only three reported cases in the literature of Takotsubo cardiomyopathy induced by opioid agonist withdrawal in adults; ours is the first reported case of iatrogenic methadone withdrawal leading to Takotsubo cardiomyopathy.
MeSH terms
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Analgesics, Opioid / administration & dosage
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Analgesics, Opioid / poisoning*
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Coronary Angiography
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Drug Overdose
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Echocardiography
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Electrocardiography
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Humans
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Iatrogenic Disease*
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Male
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Methadone / administration & dosage
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Methadone / poisoning*
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Middle Aged
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Naloxone / administration & dosage
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Naloxone / adverse effects*
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Narcotic Antagonists / administration & dosage
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Narcotic Antagonists / adverse effects*
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Opiate Substitution Treatment*
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Opioid-Related Disorders / rehabilitation*
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Takotsubo Cardiomyopathy / diagnosis
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Takotsubo Cardiomyopathy / etiology*
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Takotsubo Cardiomyopathy / therapy
Substances
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Analgesics, Opioid
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Narcotic Antagonists
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Naloxone
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Methadone