Signal amplification by magnetic force on polydiacetylene supramolecules for detection of prostate cancer

Small. 2012 Jan 23;8(2):209-13. doi: 10.1002/smll.201101322. Epub 2011 Nov 14.

Abstract

A method in which a permanent magnet is introduced onto polydiacetylene (PDA) vesicle chips is introduced for enhancement of the fluorescence of PDA vesicles. This strategy can be applied to general antibody-based PDA vesicle chips to detect clinically important biomarkers for disease diagnosis.

Keywords: magnetic beads; magnetic forces; polydiacetylene; prostate cancer; signal amplification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Immobilized
  • Antibodies, Monoclonal
  • Biosensing Techniques / methods*
  • Biosensing Techniques / statistics & numerical data
  • Biotin
  • Fluorescence
  • Humans
  • Magnetic Phenomena
  • Male
  • Microscopy, Electron, Scanning
  • Polyacetylene Polymer
  • Polymers*
  • Polyynes*
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / diagnosis*
  • Streptavidin
  • alpha 1-Antichymotrypsin / blood
  • alpha-Macroglobulins / analysis

Substances

  • Antibodies, Immobilized
  • Antibodies, Monoclonal
  • Polyacetylene Polymer
  • Polymers
  • alpha 1-Antichymotrypsin
  • alpha-Macroglobulins
  • Polyynes
  • polydiacetylene
  • Biotin
  • Streptavidin
  • Prostate-Specific Antigen