MicroRNAs: toward the clinic for breast cancer patients

Semin Oncol. 2011 Dec;38(6):764-75. doi: 10.1053/j.seminoncol.2011.08.005.

Abstract

Expression of microRNAs (miRNAs) has been found to be deregulated in all human cancers, where they may behave either as oncogenes or as tumor-suppressor genes. In the last 5 years, miRNA investigations in breast cancer represented an exciting area of discovery, which produced new knowledge on the molecular basis of this disease, tools for molecular classification, and new markers with diagnostic and prognostic relevance, as well as the discovery of novel breast cancer-predisposing genes. In this review, we describe current knowledge of the role of microRNAs in breast cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / etiology*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Epithelial-Mesenchymal Transition
  • Female
  • Humans
  • MicroRNAs / physiology*
  • Neoplasm Metastasis
  • Polymorphism, Single Nucleotide
  • Prognosis

Substances

  • MicroRNAs