Abstract
Complete sequencing of plasmid pOXA-48a carrying the bla(OXA-48) gene from a Klebsiella pneumoniae isolate was performed. Its backbone corresponded to that of an IncL/M-type plasmid, in which the bla(OXA-48) gene had been integrated through the acquisition of the Tn1999 composite transposon without any other antibiotic resistance gene. Molecular epidemiology using a collection of international OXA-48 producers revealed the wide diffusion of pOXA-48a or closely related plasmids.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Africa, Northern / epidemiology
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Anti-Bacterial Agents / therapeutic use
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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Bacterial Typing Techniques
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Base Sequence
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Carbapenems / metabolism
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Carbapenems / therapeutic use
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DNA Transposable Elements
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DNA, Bacterial / genetics
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Europe / epidemiology
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Humans
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Klebsiella Infections / drug therapy
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Klebsiella Infections / epidemiology*
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / enzymology
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Klebsiella pneumoniae / genetics*
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Microbial Sensitivity Tests
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Middle East / epidemiology
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Molecular Sequence Data
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Plasmids / genetics*
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beta-Lactam Resistance
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beta-Lactamases / chemistry
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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DNA Transposable Elements
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DNA, Bacterial
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beta-Lactamases
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carbapenemase