Triggering the production of the cryptic blue pigment indigoidine from Photorhabdus luminescens

Alexander O Brachmann; Ferdinand Kirchner; Carsten Kegler; Sebastian C Kinski; Imke Schmitt; Helge B Bode

doi:10.1016/j.jbiotec.2011.10.002

Triggering the production of the cryptic blue pigment indigoidine from Photorhabdus luminescens

J Biotechnol. 2012 Jan;157(1):96-9. doi: 10.1016/j.jbiotec.2011.10.002. Epub 2011 Nov 4.

Authors

Alexander O Brachmann¹, Ferdinand Kirchner, Carsten Kegler, Sebastian C Kinski, Imke Schmitt, Helge B Bode

Affiliation

¹ Molekulare Biotechnologie, Institut für Molekulare Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

PMID: 22085970
DOI: 10.1016/j.jbiotec.2011.10.002

Abstract

The production of the blue pigment indigoidine has been achieved in the entomopathogenic bacterium Photorhabdus luminescens by a promoter exchange and in Escherichia coli following heterologous expression of the biosynthesis gene indC. Moreover, genes involved in the regulation of this previously "silent" biosynthesis gene cluster have been identified in P. luminescens.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins / genetics
Bacterial Proteins / metabolism
Bayes Theorem
Cloning, Molecular
Escherichia coli / genetics
Escherichia coli / metabolism
Multigene Family*
Photorhabdus / genetics*
Photorhabdus / metabolism*
Phylogeny
Pigments, Biological / biosynthesis*
Piperidones / metabolism*
Promoter Regions, Genetic

Substances

Bacterial Proteins
Pigments, Biological
Piperidones
indigoidine