Objective: To investigate the effect and safety of sequential therapy of levofloxacin in the prevention of peri-operative infections among patients undergoing laparoscopic hysterectomy (LH), laparoscopic assisted vaginal hysterectomy (LAVH) and transvaginal hysterectomy (TVH).
Methods: During 2009 - 2010, a total of 50 patients with the indications for LH, LAVH or TVH at our hospital were recruited. Their age range was 18 - 65 years old. In fair general conditions, they had no severe infection of female reproductive system. Levofloxacin 500 mg was administered by an intravenous injection once daily and then orally once daily.
Results: The average duration of intravenous injection of levofloxacin was 4.3 days while and the duration of its oral administration 4.5 days. No infection was seen in 48 patients with an efficient prevention rate of 96.0%. Only 1 patient showed mild gastroenterological reactions. The side reaction rate was 2.0%.
Conclusion: The sequential therapy of levofloxacin is both effective and safe in the prevention of peri-operative infections among patients undergoing LH, LAVH and TVH.