Several guidelines are used for cancer therapy throughout the world. The Japan Gastric Cancer Association guideline, whereby standard surgery for T2 to T4 curable gastric cancer is defined as more than two-thirds gastrectomy with D2 dissection, are widely followed, with further data being gathered from either single institutions or nationwide registry. In the East, D2 dissection shows much better results than less extended surgery followed by adjuvant treatment. Adjuvant chemotherapy without radiotherapy shows significantly better survival results than surgery alone only when D2 dissection is applied. Without good local control, including regional lymph node metastasis, the cure rate cannot be high.
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