Role of the recently identified dysadherin in E-cadherin adhesion molecule downregulation in head and neck cancer

Alexandros Georgolios; Anna Eleftheriadou; Anna Batistatou; Kostandinos Charalabopoulos

doi:10.1007/s12032-011-0118-3

Role of the recently identified dysadherin in E-cadherin adhesion molecule downregulation in head and neck cancer

Med Oncol. 2012 Sep;29(3):1463-7. doi: 10.1007/s12032-011-0118-3. Epub 2011 Nov 22.

Authors

Alexandros Georgolios¹, Anna Eleftheriadou, Anna Batistatou, Kostandinos Charalabopoulos

Affiliation

¹ Department of Otorhinolaryngology, Virginia Commonwealth University, Richmond, VA, USA.

PMID: 22105147
DOI: 10.1007/s12032-011-0118-3

Abstract

Dysadherin is a cancer-related cell membrane glycoprotein, recently identified, playing an important role in tumor progression and metastasis. In the present minireview article, we are focusing on the role of dysadherin in E-cadherin downregulation, the various expression patterns of the molecule in head and neck cancer as well as its potential role as a molecular target for future applications in diagnosis, clinical routine and prognosis of the disease.

Publication types

Review

MeSH terms

Biomarkers, Tumor / metabolism*
Cadherins / metabolism*
Down-Regulation
Gene Expression Regulation, Neoplastic / physiology*
Head and Neck Neoplasms / metabolism*
Head and Neck Neoplasms / pathology
Humans
Ion Channels
Membrane Glycoproteins / metabolism*
Microfilament Proteins
Neoplasm Proteins / metabolism*

Substances

Biomarkers, Tumor
Cadherins
FXYD5 protein, human
Ion Channels
Membrane Glycoproteins
Microfilament Proteins
Neoplasm Proteins