Abstract
A five-step synthesis of the natural product angelicoin A using a late stage highly regioselective palladium(0)-catalyzed decarboxylative prenyl migration and aromatization sequence as the key step is reported. The method was extended with geranyl migration in eight-step total syntheses of hericenone J and hericenol A from geraniol.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclic Monoterpenes
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Catalysis
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Molecular Structure
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Neoprene / chemistry*
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Palladium / chemistry
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Phenols / chemical synthesis*
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Phenols / chemistry*
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Stereoisomerism
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Terpenes / chemical synthesis*
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Terpenes / chemistry*
Substances
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Acyclic Monoterpenes
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Phenols
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Terpenes
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hericenol A
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hericenone J
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prenyl
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Palladium
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Neoprene
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geraniol