High-speed AFM reveals the dynamics of single biomolecules at the nanometer scale

Allard J Katan; Cees Dekker

doi:10.1016/j.cell.2011.11.017

High-speed AFM reveals the dynamics of single biomolecules at the nanometer scale

Cell. 2011 Nov 23;147(5):979-82. doi: 10.1016/j.cell.2011.11.017.

Authors

Allard J Katan¹, Cees Dekker

Affiliation

¹ Department of Bionanoscience, Kavli Institute for Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands.

PMID: 22118456
DOI: 10.1016/j.cell.2011.11.017

Abstract

Atomic force microscopy allows visualization of biomolecules with nanometer resolution under physiological conditions. Recent advances have improved the time resolution of the technique from minutes to tens of milliseconds, meaning that it is now possible to watch single biomolecules in action in real time. Here, we review this development.

Publication types

Review

MeSH terms

Bacteria / ultrastructure
Eukaryotic Cells / ultrastructure
Microscopy, Atomic Force / methods*
Nanoparticles / chemistry
Nanoparticles / ultrastructure*
Nanotechnology / methods