Abstract
A phytochemical investigation of Monanthotaxis congoensis afforded eight polyoxygenated cyclohexenes as well as the known crotepoxide. Structures were determined using NMR, MS, and optical rotation analyses. One compound displayed moderate antiproliferative activity against NCI-H460 and M14 cancer cells.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Annonaceae / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cyclohexenes / isolation & purification
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Cyclohexenes / pharmacology
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Cyclohexenes / therapeutic use*
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Epoxy Compounds / chemistry
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Epoxy Compounds / isolation & purification
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Humans
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Molecular Structure
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Neoplasms / drug therapy*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
Substances
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Antineoplastic Agents, Phytogenic
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Cyclohexenes
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Epoxy Compounds
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Plant Extracts
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futoxide