Abstract
Five new ent-kaurane diterpenoids, isodonhenrins A-E (1-5), together with thirteen known ones were isolated from the aerial parts of Isodon henryi. Their structures were identified by means of extensive spectroscopic analysis, and the absolute configurations of 1 were determined by single-crystal X-ray diffraction. Most of the diterpenoids were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines. Compound 17 showed significant inhibitory effects on five cell lines, and compounds 6, 9, 10, 11, 12 and 16 exhibited selective activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line, Tumor
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Crystallography, X-Ray
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Diterpenes, Kaurane / chemistry*
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Diterpenes, Kaurane / isolation & purification
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Diterpenes, Kaurane / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Isodon / chemistry*
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Models, Molecular
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Neoplasms / drug therapy
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Plant Components, Aerial / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes, Kaurane