Recurrent lobar intracerebral hemorrhage in Tangier disease

Wuwei Feng; Evgeny Sidorov; Kara Smith; Magdy Selim

doi:10.1016/j.jstrokecerebrovasdis.2011.10.009

Recurrent lobar intracerebral hemorrhage in Tangier disease

J Stroke Cerebrovasc Dis. 2012 Nov;21(8):909.e5-6. doi: 10.1016/j.jstrokecerebrovasdis.2011.10.009. Epub 2011 Nov 30.

Authors

Wuwei Feng¹, Evgeny Sidorov, Kara Smith, Magdy Selim

Affiliation

¹ Department of Neurology, Division of Cerebrovascular Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

PMID: 22133743
DOI: 10.1016/j.jstrokecerebrovasdis.2011.10.009

Abstract

We report a patient with familial α-lipoprotein deficiency (Tangier disease) who presented with recurrent lobar intracerebral hemorrhages and accumulating microbleeds on T*2-weighted magnetic resonance imaging, suggestive of probable cerebral amyloid angiopathy. This case provides new insight into the links between the adenotriphosphate-binding cassette A1 (ABCA1) transporter gene mutation in Tangier disease and apolipoprotein-E expression in the brain and supports further investigation of the potential role of ABCA1 transporter in cerebral amyloid angiopathy.

Publication types

Case Reports

MeSH terms

ATP Binding Cassette Transporter 1
ATP-Binding Cassette Transporters / genetics
Apolipoproteins E / metabolism
Cerebral Amyloid Angiopathy / diagnosis
Cerebral Amyloid Angiopathy / etiology*
Cerebral Amyloid Angiopathy / metabolism
Cerebral Angiography / methods
Cerebral Hemorrhage / diagnosis
Cerebral Hemorrhage / etiology*
Cerebral Hemorrhage / metabolism
Diffusion Magnetic Resonance Imaging
Female
Humans
Middle Aged
Mutation
Recurrence
Tangier Disease / complications*
Tangier Disease / genetics
Tangier Disease / metabolism
Tomography, X-Ray Computed

Substances

ABCA1 protein, human
ATP Binding Cassette Transporter 1
ATP-Binding Cassette Transporters
Apolipoproteins E