Whole-body diffusion-weighted MRI in a case of Rosai-Dorfman disease with exclusive multifocal skeletal involvement

Skeletal Radiol. 2012 Jun;41(6):709-13. doi: 10.1007/s00256-011-1328-7. Epub 2011 Dec 3.

Abstract

Rosai-Dorfman disease (RDD) is a rare disorder and usually presents with painless bilateral cervical lymphadenopathy. About 43% of RDD patients show extranodal involvement, including bones (8%). As RDD is a systemic disease, which can involve lymph nodes, bones, skin, kidneys, respiratory tract, parotid gland, orbital cavity and the central nervous system, whole-body imaging may be useful for the assessment of extent, distribution and follow-up of disease. Whole-body diffusion-weighted MRI is able to demonstrate lesions and to assess therapy response without the need for radiation or intravenous contrast agent. Here, we report a case of a 15-year-old boy with primary skeletal RDD without lymphadenopathy, who was staged and followed by whole-body diffusion-weighted MRI.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bone Diseases / pathology*
  • Diffusion Magnetic Resonance Imaging / methods*
  • Histiocytosis, Sinus / pathology*
  • Humans
  • Male
  • Whole Body Imaging / methods*