A synthetic lipid A mimetic modulates human TLR4 activity

ChemMedChem. 2012 Feb 6;7(2):213-7. doi: 10.1002/cmdc.201100494. Epub 2011 Dec 2.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Biomimetic Materials / chemical synthesis
  • Biomimetic Materials / chemistry
  • Biomimetic Materials / pharmacology*
  • Cell Line
  • Diamide / chemistry
  • Endotoxins / toxicity
  • Glucose / chemistry
  • Humans
  • Lipid A / analogs & derivatives*
  • Lipid A / chemical synthesis
  • Lipid A / chemistry*
  • Lipid A / pharmacology*
  • Lipopolysaccharide Receptors / chemistry
  • Lipopolysaccharide Receptors / metabolism
  • Toll-Like Receptor 4 / agonists
  • Toll-Like Receptor 4 / metabolism*

Substances

  • Endotoxins
  • Lipid A
  • Lipopolysaccharide Receptors
  • Toll-Like Receptor 4
  • Diamide
  • Glucose