Abstract
Antibiotic-resistant Staphylococcus aureus is of great concern, as it causes a wide range of life-threatening infections. The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates of S. aureus in vitro in a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal infection in a subcutaneous infection model. Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylic Resins / chemistry
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Humans
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Male
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Mice
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Microspheres
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Polymers / chemistry*
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Prosthesis-Related Infections / microbiology
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Prosthesis-Related Infections / prevention & control*
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Pyrroles / chemistry
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Pyrroles / pharmacology*
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Staphylococcal Skin Infections / microbiology
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Staphylococcal Skin Infections / prevention & control*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / growth & development
Substances
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Acrylic Resins
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Anti-Bacterial Agents
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Polymers
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Pyrroles
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pyrroline
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polyacrylamide