Abstract
A multidrug-resistant Acinetobacter baumannii isolate recovered from a patient hospitalized in Switzerland after a transfer from Serbia produced the NDM-1 carbapenemase. The bla(NDM-1) gene was part of a chromosomally located Tn125 composite transposon bracketed by two copies of the same insertion sequence, ISAba125. This transposon was also associated with the acquisition and expression of the bla(NDM-2) gene in an A. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissemination of bla(NDM) genes in that species.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / epidemiology*
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Acinetobacter Infections / microbiology
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / enzymology
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Acinetobacter baumannii / genetics*
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics*
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Carbapenems / pharmacology
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DNA Transposable Elements / genetics*
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Drug Resistance, Multiple, Bacterial
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Gene Transfer, Horizontal / genetics*
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Sequence Analysis, DNA
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Switzerland / epidemiology
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beta-Lactam Resistance
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beta-Lactamases / genetics*
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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DNA Transposable Elements
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beta-Lactams
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beta-Lactamases
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beta-lactamase NDM-1
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carbapenemase
Associated data
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GENBANK/JN872328
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GENBANK/JN872329