Abstract
Very recently, it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. Its ability to kill cancer stem cells and apoptosis-resistant cancer cells may define salinomycin as a novel anticancer drug.
© 2011 John Wiley & Sons A/S.
MeSH terms
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Cell Line, Tumor
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Cyclin-Dependent Kinase Inhibitor p21 / metabolism
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DNA Damage
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Humans
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Neoplasms
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Neoplastic Stem Cells / drug effects
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Pyrans / pharmacology*
Substances
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Antineoplastic Agents
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Cyclin-Dependent Kinase Inhibitor p21
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Pyrans
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salinomycin