Use of an omega-3 fatty acid-based emulsion in the treatment of parenteral nutrition-induced cholestasis in patients with microvillous inclusion disease

J Pediatr Surg. 2011 Dec;46(12):2376-82. doi: 10.1016/j.jpedsurg.2011.09.061.

Abstract

Microvillous inclusion disease is a congenital intestinal epithelial cell disorder leading to lifelong intestinal failure. In this report, we discuss the use of a fish oil-based lipid emulsion in the treatment of 3 patients with microvillous inclusion disease who developed parenteral nutrition-associated liver disease.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acids / therapeutic use
  • Bilirubin / blood
  • Breast Feeding
  • C-Reactive Protein / analysis
  • Child, Preschool
  • Cholestasis / blood
  • Cholestasis / etiology
  • Cholestasis / therapy*
  • Diarrhea, Infantile / etiology
  • Diarrhea, Infantile / therapy
  • Electrolytes / therapeutic use
  • Emulsions / adverse effects
  • Fat Emulsions, Intravenous / adverse effects
  • Fat Emulsions, Intravenous / therapeutic use*
  • Fish Oils / therapeutic use*
  • Glucose / therapeutic use
  • Humans
  • Inclusion Bodies
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / surgery
  • Intestines / transplantation
  • Liver Diseases / etiology
  • Liver Diseases / therapy
  • Malabsorption Syndromes / complications
  • Malabsorption Syndromes / surgery
  • Malabsorption Syndromes / therapy*
  • Male
  • Microvilli / pathology
  • Mucolipidoses / complications
  • Mucolipidoses / surgery
  • Mucolipidoses / therapy*
  • Parenteral Nutrition / adverse effects*
  • Parenteral Nutrition Solutions / therapeutic use
  • Phospholipids / adverse effects*
  • Postoperative Complications / blood
  • Postoperative Complications / etiology
  • Postoperative Complications / therapy*
  • Solutions / therapeutic use
  • Soybean Oil / adverse effects*
  • Transplantation, Homologous
  • Triglycerides

Substances

  • Amino Acids
  • Electrolytes
  • Emulsions
  • Fat Emulsions, Intravenous
  • Fish Oils
  • Parenteral Nutrition Solutions
  • Phospholipids
  • Solutions
  • Triglycerides
  • amino-acid, glucose, and electrolyte solution
  • fish oil triglycerides
  • soybean oil, phospholipid emulsion
  • Soybean Oil
  • C-Reactive Protein
  • Glucose
  • Bilirubin

Supplementary concepts

  • Microvillus inclusion disease