Preoperative radiation therapy for upper rectal cancer T3,T4/Nx: selectivity essential

Sarah Popek; Vassiliki Liana Tsikitis; Lisa Hazard; Alfred M Cohen

doi:10.1016/j.clcc.2011.06.009

Preoperative radiation therapy for upper rectal cancer T3,T4/Nx: selectivity essential

Clin Colorectal Cancer. 2012 Jun;11(2):88-92. doi: 10.1016/j.clcc.2011.06.009. Epub 2011 Dec 6.

Authors

Sarah Popek¹, Vassiliki Liana Tsikitis, Lisa Hazard, Alfred M Cohen

Affiliation

¹ Department of Surgery, Section of Surgical Oncology, University Medical Center, University of Arizona, Tucson, AZ, USA.

PMID: 22154165
DOI: 10.1016/j.clcc.2011.06.009

Abstract

This review explores the current available literature regarding the role of neoadjuvant therapy for upper locally advanced rectal cancers (≥10 cm-15 cm). Although there is a paucity of data evaluating the outcomes of preoperative chemoradiation for upper rectal cancers the authors suggest that T3N0 tumors will not likely benefit from radiation and that treatment of T4N0 should be individualized.

Publication types

Review

MeSH terms

Clinical Trials as Topic
Humans
Neoadjuvant Therapy / methods*
Neoplasm Staging
Radiotherapy / methods*
Rectal Neoplasms / pathology*
Rectal Neoplasms / radiotherapy*
Rectal Neoplasms / surgery