Chemical constituents of the fermented broth of the ascomycete Theissenia cinerea 89091602

Chem Biodivers. 2011 Dec;8(12):2285-90. doi: 10.1002/cbdv.201000329.

Abstract

One new betaenone, theissenoic acid (1), together with three new acetogenins, theissenolactones A-C (2-4, resp.), were isolated from the fermented broth of Theissenia cinerea 89091602 isolated in Taiwan. The structures of 1-4 were elucidated by spectroscopic methods. Biological tests revealed that 3 and 4 exhibited moderate growth-inhibitory activities against A549 lung cancer cell line with GI(50) values of 14.9 and 47.9 μM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetogenins / chemistry*
  • Acetogenins / isolation & purification*
  • Acetogenins / pharmacology
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Chromatography, High Pressure Liquid
  • Drug Screening Assays, Antitumor
  • Fermentation
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Xylariales / chemistry*
  • Xylariales / growth & development

Substances

  • 2,3,7,7a-tetrahydro-3-hydroxy-7-methyl-2-(prop-1-en-1-yl)-5H-furo(3,4-b)pyran-5-one
  • Acetogenins
  • Antineoplastic Agents