Abstract
While investigating the cytotoxic activity of the methanol extract of an Australian marine sponge Stelletta sp. (Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with the known bengamides; A (2), F (3), N (4), Y (5), and bengazoles; Z (6), C(4) (7) and C(6) (8). The isolation and structure elucidation of the diketopiperazine (1), together with the activity of 1-8 against a panel of human and mammalian cell lines are discussed.
Keywords:
Stelletta; anti-cancer activity; bengamide; bengazole; cyclo-(4-S-hydroxy-R-proline-R-isoleucine); diketopiperazine (DKP).
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Australia
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Azepines / chemistry
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Azepines / isolation & purification
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Azepines / pharmacology*
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Cell Line
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Cell Line, Tumor
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Diketopiperazines / chemistry
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Diketopiperazines / isolation & purification
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Diketopiperazines / pharmacology*
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Humans
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Neoplasms / drug therapy
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Neoplasms / pathology
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Oxazoles / chemistry
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Oxazoles / isolation & purification
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Oxazoles / pharmacology*
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification
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Peptides, Cyclic / pharmacology*
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Porifera / chemistry*
Substances
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Antineoplastic Agents
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Azepines
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Diketopiperazines
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Oxazoles
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Peptides, Cyclic
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cyclo-(4-S-hydroxy-R-proline-R-isoleucine)