Abstract
Five zoanthoxanthin alkaloids (1-5) and four sesquiterpenes (6-9) were isolated from the South China Sea gorgonian Echinogorgia pseudossapo. Their structures were determined on the bases of extensive spectroscopic analyses, including 1D and 2D NMR data. Among them, pseudozoanthoxanthins III and IV (1-2), 8-hydroxy-6β-methoxy-14- oxooplop-6,12-olide (6) and 3β-methoxyguaian-10(14)-en-2β-ol (7) were new, 1 and 3 showed mild anti-HSV-1 activity, and 7 showed significant antilarval activity towards Balanus amphitrite larvae.
Keywords:
Echinogorgia pseudossapo; gorgonian; sesquiterpene; zoanthoxanthin alkaloid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Animals
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Anthozoa / chemistry*
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology
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China
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Chlorocebus aethiops
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Imidazoles / chemistry
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Imidazoles / isolation & purification
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Imidazoles / pharmacology
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Larva / drug effects
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Magnetic Resonance Spectroscopy / methods
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Oceans and Seas
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Thoracica / drug effects
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Vero Cells
Substances
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Alkaloids
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Antiviral Agents
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Imidazoles
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Sesquiterpenes
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zoanthoxantin