Formal synthesis of antiplatelet drug, beraprost

Org Lett. 2012 Jan 6;14(1):299-301. doi: 10.1021/ol203060v. Epub 2011 Dec 14.

Abstract

The first stereocontrolled and enantiospecific formal synthesis of antiplatelet drug beraprost has been achieved from readily available 1-tetralone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Epoprostenol / analogs & derivatives*
  • Epoprostenol / chemical synthesis
  • Epoprostenol / chemistry
  • Molecular Structure
  • Platelet Aggregation Inhibitors / chemical synthesis*
  • Stereoisomerism

Substances

  • Platelet Aggregation Inhibitors
  • beraprost
  • Epoprostenol