Abstract
Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944-2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn glycoprotein gene showed that 95 unique sequences sorted into 15 lineages. A 2010 isolate from a patient in South Africa potentially exposed to co-infection with live animal vaccine and wild virus was a reassortant. The potential influence of large-scale use of live animal vaccine on evolution of Rift Valley fever virus is discussed.
MeSH terms
-
Animals
-
Base Sequence
-
Communicable Diseases, Emerging / epidemiology
-
Communicable Diseases, Emerging / veterinary
-
Communicable Diseases, Emerging / virology
-
DNA, Viral / genetics
-
Disease Outbreaks / veterinary
-
Genes, Viral
-
Humans
-
Molecular Epidemiology
-
Phylogeny
-
Recombination, Genetic
-
Rift Valley Fever / epidemiology
-
Rift Valley Fever / veterinary*
-
Rift Valley Fever / virology
-
Rift Valley fever virus / classification*
-
Rift Valley fever virus / genetics*
-
Rift Valley fever virus / isolation & purification
-
Ruminants
-
Saudi Arabia / epidemiology
-
South Africa / epidemiology
-
Viral Proteins / genetics
-
Viral Vaccines / genetics
Substances
-
DNA, Viral
-
Viral Proteins
-
Viral Vaccines