Receptor antibodies as novel therapeutics for diabetes

Sci Transl Med. 2011 Dec 14;3(113):113ps47. doi: 10.1126/scitranslmed.3003447.

Abstract

Antibodies to receptors can block or mimic hormone action. Taking advantage of receptor isoforms, co-receptors, and other receptor modulating proteins, antibodies and other designer ligands can enhance tissue specificity and provide new approaches to the therapy of diabetes and other diseases.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use*
  • Diabetes Mellitus, Type 2 / therapy*
  • Female
  • Fibroblast Growth Factors / metabolism*
  • Humans
  • Male
  • Receptor, Fibroblast Growth Factor, Type 1 / metabolism*

Substances

  • Antibodies, Monoclonal
  • fibroblast growth factor 21
  • Fibroblast Growth Factors
  • Receptor, Fibroblast Growth Factor, Type 1