Abstract
The influence of vitamin D on influenza vaccine immunogenicity in HIV was assessed using data from a phase 3, randomized trial conducted during the 2008-2009 influ-enza season. Thirty-three percent of participants were on supplemental vitamin D at baseline. Neither seroconversion nor seroprotection were predicted by vitamin D use for any of the 3 vaccine strains. There is no evidence of improved influenza vaccine immunogenicity with vitamin D supplementation in this HIV-positive population.
Publication types
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Clinical Trial, Phase III
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Antibodies, Viral / blood*
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Child
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Dietary Supplements*
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Female
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HIV / physiology
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HIV Infections / immunology*
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Humans
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Influenza A Virus, H1N1 Subtype / immunology
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Influenza A Virus, H3N2 Subtype / immunology
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Influenza B virus / immunology
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Influenza Vaccines / administration & dosage
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Influenza Vaccines / immunology*
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Influenza, Human / immunology
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Influenza, Human / prevention & control*
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Male
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Middle Aged
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Seasons
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Treatment Outcome
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Vitamin D / administration & dosage
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Vitamin D / immunology*
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Young Adult
Substances
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Antibodies, Viral
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Influenza Vaccines
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Vitamin D