Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: a favorable endogenous response

Ramesh Kumar; Archana Rastogi; J S Maras; Shiv Kumar Sarin

doi:10.1016/j.clinbiochem.2011.11.017

Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: a favorable endogenous response

Clin Biochem. 2012 Feb;45(3):272-4. doi: 10.1016/j.clinbiochem.2011.11.017. Epub 2011 Dec 16.

Authors

Ramesh Kumar¹, Archana Rastogi, J S Maras, Shiv Kumar Sarin

Affiliation

¹ Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi-110070, India. [email protected]

PMID: 22198578
DOI: 10.1016/j.clinbiochem.2011.11.017

Abstract

The clinical significance of increased frequency of unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease (NAFLD) is unknown. Serum bilirubin is an endogenous anti-oxidant, and oxidative stress plays an important role in the pathogenesis of NAFLD. In this study, we have documented 25.4% prevalence of unconjugated hyperbilirubinemia in 204 consecutive NAFLD patients. These patients had a significantly less severe liver disease on histopathology and/or fibroScan which may be attributed to anti-oxidant effect of bilirubin.

MeSH terms

Adult
Bilirubin / blood
Demography
Elasticity Imaging Techniques
Fatty Liver / blood
Fatty Liver / complications*
Fatty Liver / pathology
Female
Humans
Hyperbilirubinemia / blood
Hyperbilirubinemia / complications*
Hyperbilirubinemia / pathology
Male
Non-alcoholic Fatty Liver Disease
Severity of Illness Index

Substances

Bilirubin