[A case of complete response to interferon-α and S-1 combination therapy for multiple pulmonary recurrences of hepatocellular carcinoma after hepatic resection]

Gan To Kagaku Ryoho. 2011 Nov;38(12):2487-9.
[Article in Japanese]

Abstract

A 77-year-old man was diagnosed as hepatocellular carcinoma, and was referred to our hospital. After he was treated by transcatheter chemoembolization, he underwent a left hepatic lobectomy of the liver and cholecystectomy. Serum AFP and PIVKA-II remarkably elevated 7 months after surgery, and CT scan revealed multiple metastatic nodules in bilateral lungs. The nodules were diagnosed as lung metastasis of HCC. Because the lesions grew larger, S-1/IFN was administered. Diagnostic imaging and tumor markers showed a marked improvement after 4 courses of S-1/IFN therapy, and he is still alive with good condition without recurrence and progression of tumors.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Carcinoma, Hepatocellular / drug therapy*
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / therapy
  • Drug Combinations
  • Embolization, Therapeutic
  • Hepatectomy
  • Humans
  • Interferon-alpha / administration & dosage
  • Interferon-alpha / therapeutic use*
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / pathology
  • Liver Neoplasms / therapy
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / secondary
  • Male
  • Oxonic Acid / administration & dosage
  • Oxonic Acid / therapeutic use*
  • Recurrence
  • Remission Induction
  • Tegafur / administration & dosage
  • Tegafur / therapeutic use*
  • Tomography, X-Ray Computed

Substances

  • Drug Combinations
  • Interferon-alpha
  • S 1 (combination)
  • Tegafur
  • Oxonic Acid