Rho GTPases: masters of T lymphocyte migration and activation

Pablo Rougerie; Jérôme Delon

doi:10.1016/j.imlet.2011.12.003

Rho GTPases: masters of T lymphocyte migration and activation

Immunol Lett. 2012 Feb 29;142(1-2):1-13. doi: 10.1016/j.imlet.2011.12.003. Epub 2011 Dec 21.

Authors

Pablo Rougerie¹, Jérôme Delon

Affiliation

¹ Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, CNRS (UMR 8104), Paris, France; Inserm, U1016, Paris, France.

PMID: 22207038
DOI: 10.1016/j.imlet.2011.12.003

Abstract

Rho GTPases are key signal transducer elements activated in T cells by both chemokine and antigen receptors. These two signalling pathways control the two main functions of T lymphocytes: motility and activation. Rho GTPases are thus crucial for the development of an adequate immune response. In this review, we mostly focus on the roles of RhoA, Rac1 and Cdc42 in T cells. We show their importance in phenomena such as adhesion, morphological polarization, migration and antigen recognition.

Publication types

Review

MeSH terms

Cell Movement*
Lymphocyte Activation / immunology*
Signal Transduction
T-Lymphocytes / immunology*
T-Lymphocytes / physiology
rho GTP-Binding Proteins / metabolism*

Substances

rho GTP-Binding Proteins