Abstract
There has been speculation that chronic HIV infection is a condition of accelerated aging that may lead to early onset of disease in multiple organ systems. The neuromuscular disorders of HIV, in particular distal symmetric polyneuropathy and myopathies, are also seen in the general population among older patients. As the HIV-infected population ages, there may be deleterious synergistic effects of age and chronic HIV infection on the brain, peripheral nerve, and muscle. In this review, we explore commonalities between the clinical features and putative mechanisms of neuromuscular disorders and HIV.
MeSH terms
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Aging*
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Analgesics / administration & dosage
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Analgesics / therapeutic use
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Anti-HIV Agents / administration & dosage
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Anti-HIV Agents / therapeutic use
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Brain / physiopathology
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HIV Infections / complications
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HIV Infections / drug therapy
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HIV Infections / physiopathology*
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Humans
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Life Expectancy
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Muscle, Skeletal / physiopathology
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Neuralgia / complications
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Neuralgia / drug therapy
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Neuralgia / physiopathology*
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Neuromuscular Diseases / complications
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Neuromuscular Diseases / drug therapy
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Neuromuscular Diseases / physiopathology*
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Peripheral Nerves / physiopathology
Substances
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Analgesics
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Anti-HIV Agents