Humanized mice for the study of type 1 and type 2 diabetes

Ann N Y Acad Sci. 2011 Dec:1245:55-8. doi: 10.1111/j.1749-6632.2011.06318.x.

Abstract

The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 1 / etiology*
  • Diabetes Mellitus, Type 2 / etiology*
  • Disease Models, Animal
  • HLA Antigens / genetics
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Hyperglycemia / etiology
  • Interleukin Receptor Common gamma Subunit / deficiency
  • Interleukin Receptor Common gamma Subunit / genetics
  • Islets of Langerhans Transplantation
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Mice, Transgenic
  • Transplantation, Heterologous

Substances

  • HLA Antigens
  • Il2rg protein, mouse
  • Interleukin Receptor Common gamma Subunit