Hypervolemia, a potential complication in patients on ventricular assist device support, can be managed by use of continuous arteriovenous hemofiltration. The Hemopump, a new catheter-mounted, transaortic axial-flow ventricular assist device, and the vascular access catheter for the Diafilter-30 Hemofilter system, used in continuous arteriovenous hemofiltration, are both usually inserted by way of the femoral artery. Because placing two large catheters in the femoral artery of a patient with peripheral vascular disease can compromise circulation, a technique for placing them in the abdominal aorta was developed. Two patients have undergone combined Hemopump and hemofiltration treatment, and neither experienced complications. Such techniques may benefit more patients in the future, as the usefulness of the Hemopump is proved.