Abstract
Enteropathy-associated T-cell lymphoma (EATL) is a rare non-Hodgkin lymphoma frequently associated with celiac disease. We report a case of EATL complicating adult autoimmune enteropathy (AIE). Analysis of phenotype, rearrangements in T-cell receptor genes, and chromosome alterations by high-resolution comparative genomic hybridization identified features distinct from those described for types I and II EATL. Furthermore, EATL arose from a single T-cell clone that had been present for several years in AIE-associated, oligoclonal, intestinal T-cell infiltrate. Emerging T-cell clones should be monitored in patients with AIE who receive long-term immunosuppressive therapy.
Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Biopsy
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Clone Cells / immunology
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Clone Cells / pathology
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Comparative Genomic Hybridization
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Enteropathy-Associated T-Cell Lymphoma / etiology*
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Enteropathy-Associated T-Cell Lymphoma / genetics
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Enteropathy-Associated T-Cell Lymphoma / immunology
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Enteropathy-Associated T-Cell Lymphoma / pathology
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Female
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Gene Rearrangement, T-Lymphocyte
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Genes, T-Cell Receptor*
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Genetic Predisposition to Disease
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Humans
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Immunosuppressive Agents / therapeutic use
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Intestinal Neoplasms / etiology*
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Intestinal Neoplasms / genetics
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Intestinal Neoplasms / immunology
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Intestinal Neoplasms / pathology
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Middle Aged
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Phenotype
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Polyendocrinopathies, Autoimmune / complications*
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Polyendocrinopathies, Autoimmune / drug therapy
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Polyendocrinopathies, Autoimmune / immunology