Abstract
The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adult
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Apoptosis Regulatory Proteins / genetics
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Brazil
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CARD Signaling Adaptor Proteins / genetics
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Calcium-Binding Proteins / genetics
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Carrier Proteins / genetics
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Caspase 1 / genetics
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Female
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Gene Frequency
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Genetic Predisposition to Disease*
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Genotype
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HIV Infections / genetics*
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HIV-1*
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Humans
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Inflammasomes / genetics*
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Interleukin-1beta / genetics
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Intracellular Signaling Peptides and Proteins / genetics*
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Male
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Middle Aged
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NLR Family, Pyrin Domain-Containing 3 Protein
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NLR Proteins
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Neoplasm Proteins / genetics
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Polymorphism, Single Nucleotide*
Substances
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Adaptor Proteins, Signal Transducing
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Apoptosis Regulatory Proteins
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CARD Signaling Adaptor Proteins
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CARD8 protein, human
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Calcium-Binding Proteins
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Carrier Proteins
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IL1B protein, human
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Inflammasomes
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Interleukin-1beta
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Intracellular Signaling Peptides and Proteins
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NLR Family, Pyrin Domain-Containing 3 Protein
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NLR Proteins
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NLRC4 protein, human
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NLRP1 protein, human
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NLRP3 protein, human
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Neoplasm Proteins
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Caspase 1