Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL)

Leukemia. 2012 Jul;26(7):1689-92. doi: 10.1038/leu.2012.6. Epub 2012 Jan 12.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • B-Lymphocytes / cytology
  • B-Lymphocytes / metabolism*
  • Blotting, Western
  • Case-Control Studies
  • DNA Methylation*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / enzymology*
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Mitogen-Activated Protein Kinase 1 / genetics
  • Mitogen-Activated Protein Kinase 1 / metabolism
  • Mitogen-Activated Protein Kinase 3 / genetics
  • Mitogen-Activated Protein Kinase 3 / metabolism
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism*
  • Phosphoprotein Phosphatases / genetics*
  • Phosphoprotein Phosphatases / metabolism*
  • Phosphorylation
  • Promoter Regions, Genetic / genetics
  • Protein Kinase C / genetics
  • Protein Kinase C / metabolism
  • Protein Kinase C beta
  • Proto-Oncogene Proteins c-akt / genetics
  • Proto-Oncogene Proteins c-akt / metabolism
  • RNA Stability
  • RNA, Messenger / genetics
  • Real-Time Polymerase Chain Reaction
  • Receptors, CXCR4 / genetics
  • Receptors, CXCR4 / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tumor Cells, Cultured

Substances

  • CXCR4 protein, human
  • Nuclear Proteins
  • RNA, Messenger
  • Receptors, CXCR4
  • Proto-Oncogene Proteins c-akt
  • Protein Kinase C
  • Protein Kinase C beta
  • MAPK1 protein, human
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
  • PHLPP1 protein, human
  • Phosphoprotein Phosphatases