Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines

Mol Divers. 2012 Feb;16(1):73-9. doi: 10.1007/s11030-011-9354-x. Epub 2012 Jan 12.

Abstract

Three scaffolds of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines were synthesized via Ugi/de-protection/cyclization methodology. Benzimidazole forming ring closure was enabled under microwave irradiation in the presence of 10% TFA/DCE. The methodology demonstrates the utility of 2-(N-Boc-amino)-phenyl-isocyanide for the generation of new molecular diversity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Benzimidazoles / chemical synthesis*
  • Benzimidazoles / chemistry
  • Chemistry, Organic / methods*
  • Molecular Conformation
  • Quinolines / chemical synthesis*
  • Quinolines / chemistry
  • X-Rays

Substances

  • Benzimidazoles
  • Quinolines
  • bis-benzimidazole
  • benzimidazole