Detection of human bocavirus in the cerebrospinal fluid of children with encephalitis

Marcelo Takahiro Mitui; S M Shahnawaz Bin Tabib; Takashi Matsumoto; Wahida Khanam; Selim Ahmed; Daisuke Mori; Nasima Akhter; Kentaro Yamada; Luthful Kabir; Akira Nishizono; Maria Söderlund-Venermo; Kamruddin Ahmed

doi:10.1093/cid/cir957

Detection of human bocavirus in the cerebrospinal fluid of children with encephalitis

Clin Infect Dis. 2012 Apr;54(7):964-7. doi: 10.1093/cid/cir957. Epub 2012 Jan 11.

Authors

Marcelo Takahiro Mitui¹, S M Shahnawaz Bin Tabib, Takashi Matsumoto, Wahida Khanam, Selim Ahmed, Daisuke Mori, Nasima Akhter, Kentaro Yamada, Luthful Kabir, Akira Nishizono, Maria Söderlund-Venermo, Kamruddin Ahmed

Affiliation

¹ Department of Microbiology, Faculty of Medicine, Oita University, Yufu, Japan.

PMID: 22238160
DOI: 10.1093/cid/cir957

Abstract

We report 4 children with encephalitis associated with human bocavirus (HBoV) 1 or 2. All children were severely underweight, and 2 died; 1 of them had a matching HBoV2 nucleotide sequence isolated from serum and bocavirus like particles in the cerebrospinal fluid that were observed with electron microscopy. No further pathogens were detected in the cerebrospinal fluid of these patients.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Cerebrospinal Fluid / virology*
Child
Child, Preschool
DNA, Viral / chemistry
DNA, Viral / genetics
Encephalitis, Viral / diagnosis*
Encephalitis, Viral / virology
Female
Human bocavirus / isolation & purification*
Humans
Infant
Male
Microscopy, Electron
Molecular Sequence Data
Parvoviridae Infections / diagnosis*
Parvoviridae Infections / virology
Sequence Analysis, DNA
Virion / ultrastructure

Substances

DNA, Viral

Associated data

GENBANK/AB666091
GENBANK/AB666092
GENBANK/AB666093
GENBANK/AB666094
GENBANK/AB666095