Is blood ammonia influenced by kidney function? A prospective study

Muhammad Imran; Yaser Shah; Seema Nundlall; Norman B Roberts; Matthew Howse

doi:10.1016/j.clinbiochem.2011.12.015

Is blood ammonia influenced by kidney function? A prospective study

Clin Biochem. 2012 Mar;45(4-5):363-5. doi: 10.1016/j.clinbiochem.2011.12.015. Epub 2012 Jan 3.

Authors

Muhammad Imran¹, Yaser Shah, Seema Nundlall, Norman B Roberts, Matthew Howse

Affiliation

¹ Department of Nephrology, Royal Liverpool and Broadgreen University Hospital NHS Trust, Liverpool, UK.

PMID: 22240068
DOI: 10.1016/j.clinbiochem.2011.12.015

Abstract

Background: We have investigated whether blood ammonia is increased with worsening CKD.

Methods: Fifty eight subjects with a range of CKD were recruited for analysis of plasma ammonia and other electrolytes.

Results: The concentrations of plasma ammonia were all within the normal reference range and there was no correlation between ammonia and CKD without any effect of dialysis.

Conclusions: Blood ammonia is not elevated in or related to the severity of chronic kidney disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Ammonia / blood*
Bicarbonates / blood
Creatinine / blood
Glomerular Filtration Rate
Humans
Kidney / physiopathology*
Middle Aged
Prospective Studies
Renal Dialysis
Renal Insufficiency, Chronic / blood*
Renal Insufficiency, Chronic / physiopathology*
Renal Insufficiency, Chronic / therapy
Severity of Illness Index
Urea / blood
Uremia / blood
Uremia / physiopathology
Uremia / therapy
Young Adult

Substances

Bicarbonates
Ammonia
Urea
Creatinine